Foldit is an experimental video game about protein folding, developed as a collaboration between the University of Washington's departments of Computer Science and Engineering and Biochemistry (many of the same people who created Rosetta@home).
Basically, some biochemists were watching their folding@home screensavers and would often see the computer get it wrong, "Oh man, if it only rotated that hydrogen backbone ring left instead of right it would have folded to a much lower energy state".
So - armed with this suggestion that perhaps humans could actually do a better job at folding than computers could - some ppl from University of Washington worked on creating a protein folding game that combines folding@home simulation with user input. You compete with the computer simulation and other players on the online scoreboard to find the lowest energy state of random proteins, earning points.
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